Th17 lineage
Gene co-expression module in CD4⁺ T cells
| Category | Th17 fate |
|---|---|
| Genes | 22 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 22 genes have a known function matching the annotation |
Why this annotation
This module is anchored by canonical Th17 lineage genes: RORC (master Th17 transcription factor), IL23R (Th17 maintenance receptor), IL17RE, and ITGB7 (gut-homing integrin). Strong positive association with CD inflammation. Neighbor of M31 (also Th17/IL17A), reinforcing a coherent Th17 fate program. RORC + IL23R + IL17RE + ITGB7 + NR1D1 (circadian regulator of Th17) constitute the core.
Genes
ADA, ARHGEF3, CD226, CD52, DENND3, EVL, IDH2, IL17RE, IL23R, IQCG, ITGB7, LST1, MCOLN2, MSC, NFATC2, NMI, NR1D1, RHBDF2, RORC, SH3BP1, SYTL1, TNFSF10
Most correlated modules
- Cytotoxic effector · correlation 0.84
- Rho-GTPase Migration · correlation 0.83
- Th17 effector · correlation 0.83
- Inflammatory activation · correlation 0.80
- T cell co-receptors · correlation 0.80
- Actin Cytoskeleton · correlation 0.77
- Gamma-delta T cell · correlation 0.76
- Cell motility/adhesion · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.