Actomyosin signaling
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
Hubs include TBL1XR1 (NCoR/SMRT corepressor, NFkB signaling), ROCK1 and PPP1R12A (Rho/actomyosin cytoskeletal regulation), NCKAP1L (HEM1, actin/WAVE complex), PRKCH, PTPRA, TAOK3 — signaling and cytoskeletal regulators. SIRPG is a T-cell surface marker. The module mixes signaling and cytoskeletal regulation; ROCK1/PPP1R12A/NCKAP1L point to actomyosin/migration machinery, fitting a CD4 T cell activation/migration program elevated in inflammation.
Genes
ACIN1, CYBC1, EIF4G3, GALNT1, HNRNPA3, NCKAP1L, PPP1R12A, PRKCH, PTPRA, ROCK1, SIRPG, SPPL2A, SUSD6, TAOK3, TBL1XR1, TRIP12, XRN1
Most correlated modules
- Activated effector Tcell · correlation 0.88
- Interferon-stimulated genes · correlation 0.87
- mRNA splicing · correlation 0.86
- Mitochondrial OxPhos · correlation 0.84
- Proteasome translation · correlation 0.83
- NF-kB feedback · correlation 0.83
- Integrin Rap1 Signaling · correlation 0.82
- Cell cycle regulators · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.