Membrane trafficking
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 28 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
Mixed module with cohesin (RAD21), chromatin (SMYD3, NONO), autophagy/ubiquitin (NBR1, MIB1, NUMB), vesicle trafficking (RAB30, NAPG, YIPF4, YIPF6), and metabolic (HSDL2, GLB1, OGA, HPSE) genes. No single dominant program; mostly housekeeping/cell-maintenance genes co-expressed in an activation state. HPSE (heparanase) and RAD21 hint at activation/proliferation. Best classified as general housekeeping.
Genes
BCL2, CLSTN1, GLB1, GTF2I, HPSE, HSDL2, LENG8, MBIP, MCF2L2, MIB1, MRPS18C, NAPG, NBR1, NOL7, NONO, NUMB, OGA, PDS5B, PYHIN1, RAB30, RAD21, SMYD3, SRSF4, VPS26A, YIPF4, YIPF6, YPEL2, ZFAND3
Most correlated modules
- NF-kB regulation · correlation 0.92
- Cellular biosynthesis · correlation 0.91
- Vesicle trafficking · correlation 0.86
- T-cell activation · correlation 0.85
- Proteasome/translation · correlation 0.82
- RNA processing splicing · correlation 0.79
- ER-Golgi Trafficking · correlation 0.77
- DNA damage response · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.