Actin Cytoskeleton
Gene co-expression module in CD4⁺ T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
High expression, broadly detected module containing cytoskeletal/actin genes (MYL12B, CFL1, CAPZB, SH3BGRL3, ABRACL), proteasome activator (PSME1, PSME2), ER translocon (SEC61B, SEC61G), and housekeeping (PPIB, GUK1). Hub MYL12B (myosin light chain) plus cofilin and CapZ point to actomyosin cytoskeleton, but mixed with proteasome/ER. Low inflammation association, high baseline expression — likely a housekeeping/cytoskeletal maintenance program.
Genes
ABRACL, CAPZB, CD53, CFL1, CKLF, DRAP1, GUK1, MYL12B, PPIB, PSME1, PSME2, SEC61B, SEC61G, SH3BGRL3, SSBP4
Most correlated modules
- Cell motility/adhesion · correlation 0.85
- Integrin Adhesion Migration · correlation 0.82
- Actin cytoskeleton · correlation 0.80
- Oxidative Phosphorylation · correlation 0.78
- Th17 lineage · correlation 0.77
- ER stress UPR · correlation 0.77
- Effector Immune Activation · correlation 0.75
- Rho-GTPase Migration · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.