Inflammatory activation
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes IL32 (pro-inflammatory cytokine), CORO1A, SIT1, VAMP5/VAMP8 (immune vesicle trafficking), HLA-A, B2M (antigen presentation), ACP5, CHST11. The mixture of MHC class I (HLA-A, B2M), T cell signaling (SIT1, CORO1A), and IL32 reflects an inflammatory/activated T cell state with antigen-presentation/interferon influence. SOX4 is a developmental TF. Moderate coherence indicates mixed program but overall inflammatory activation dominates.
Genes
ACP5, B2M, CALCOCO1, CCNG2, CHST11, CORO1A, HLA-A, IL32, PITPNM2, POLR3GL, RAB38, REXO2, SETD7, SIT1, SLC35E3, SNRNP35, SOX4, VAMP5, VAMP8
Most correlated modules
- Activated effector Tcell · correlation 0.88
- NF-kB feedback · correlation 0.88
- Th1 IL12 response · correlation 0.88
- MAPK feedback signaling · correlation 0.85
- Interferon Response · correlation 0.83
- Interferon-stimulated genes · correlation 0.82
- Actomyosin signaling · correlation 0.81
- Cell cycle regulators · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.