Proteasome translation
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes dominated by proteasome subunits (PSMD7, PSMD14, ADRM1), translation/RNA-binding factors (EIF3J, SERBP1, CDV3), and metabolic/stress genes (ENO1, HSBP1, MAPKAPK2). This is a housekeeping proteostasis/translation module. SH2D2A and CST7 add minor T-cell activation flavor, but the network identity is proteasome/translation machinery, consistent with a metabolically active proliferating/activated cell. Mild inflammation association likely reflects general activation-driven biosynthesis.
Genes
ADRM1, CD2BP2, CDV3, CST7, EHBP1L1, EIF3J, ENO1, HSBP1, MAPKAPK2, PSMD14, PSMD7, SDF4, SERBP1, SH2D2A
Most correlated modules
- Mitochondrial OxPhos · correlation 0.93
- ER protein processing · correlation 0.92
- Activated effector Tcell · correlation 0.91
- Interferon-stimulated genes · correlation 0.91
- Th1 IL12 response · correlation 0.87
- Proteostasis OxPhos · correlation 0.86
- TNF activation survival · correlation 0.83
- Actomyosin signaling · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.