Oxidative Phosphorylation
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes are overwhelmingly mitochondrial OxPhos components: UQCR11 (complex III), COX5B/COX6C/COX6A1/COX8A (complex IV), ATP5F1E (ATP synthase). Mixed with a few small genes (YPEL3, SH3BGRL, DYNLRB1, GMFG). TRBC2 is a T cell receptor gene confirming T cell identity. Clear OxPhos/electron transport chain module.
Genes
ATP5F1E, BLOC1S1, COX5B, COX6A1, COX6C, COX8A, DYNLRB1, GMFG, SH3BGRL, SNX6, SYF2, TPR, TRBC2, UQCR11, YPEL3
Most correlated modules
- Proteostasis OxPhos · correlation 0.87
- Oxidative Phosphorylation · correlation 0.87
- Mitochondrial OxPhos · correlation 0.81
- Activated effector Tcell · correlation 0.81
- RNA & Chromatin Regulation · correlation 0.80
- RNA processing splicing · correlation 0.80
- Interferon-stimulated genes · correlation 0.80
- Actin cytoskeleton · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.