CD4 Lineage Identity
Gene co-expression module in CD4⁺ T cells
| Category | T cell development |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 15 genes have a known function matching the annotation |
Why this annotation
Mixed module of transcription factors and metabolic genes. ZBTB7B (ThPOK, master CD4 lineage TF), RFX5 (MHC-II transactivator), ATF2 (AP-1 family TF), PPM1A (phosphatase, TGF-beta/NF-kB regulation). Also metabolic enzymes ACAA1 (fatty acid oxidation), AGPAT3 (lipid synthesis), SEPHS2, SLC6A6 transporter. ZBTB7B is a strong CD4 T cell identity marker. Module reflects broad CD4 T cell housekeeping/identity transcriptional program rather than a single sharp program; uniform low expression. ThPOK and RFX5 anchor CD4 lineage identity.
Genes
ACAA1, AGPAT3, ASCC3, ATF2, KIFAP3, KXD1, NEK7, PARP4, PPM1A, RFX5, SEPHS2, SLC6A6, TMEM60, VAMP4, ZBTB7B
Most correlated modules
- Vesicle Trafficking Signaling · correlation 0.98
- Mitochondrial Translation · correlation 0.94
- Leukocyte Motility · correlation 0.93
- Lipid Metabolism · correlation 0.92
- Immune Regulation · correlation 0.85
- T Cell Signaling · correlation 0.85
- Membrane Trafficking · correlation 0.83
- mRNA Processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.