Integrin adhesion
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
Hubs include SYNE1 (nesprin, nuclear-cytoskeletal linkage), MYO7A (myosin), PDE4DIP, CEP85L (centrosome), and the leukocyte integrin ITGAL (LFA-1) and CD84 (SLAM family adhesion). RAB37, CYTH1 (cytohesin, integrin activation), ATP11B. The combination of cytoskeletal/centrosomal genes and adhesion molecules (ITGAL, CD84, CYTH1) points to a migration/adhesion program with cytoskeletal organization. Inflammation-upregulated. ITGAL and CYTH1 strongly support leukocyte adhesion.
Genes
ATP11B, CD84, CEP85L, CYTH1, HTRA1, ITGAL, MYO7A, PCNX2, PDE4DIP, PPM1M, RAB37, RICTOR, SYNE1
Most correlated modules
- Integrin Rap1 Signaling · correlation 0.75
- Th17 effector · correlation 0.71
- Post-transcriptional regulation · correlation 0.69
- Tfh IL21 help · correlation 0.65
- Immune regulation · correlation 0.60
- Transcription/RNA processing · correlation 0.60
- NFAT activation · correlation 0.58
- Cytotoxic effector · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.