Cytoskeleton & metabolism
Gene co-expression module in CD4⁺ T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Mixed module: actin/cytoskeleton (CAP1, BRK1, MYL6, TPM3, RAC2, PPP1R18), ATP synthase/OxPhos (ATP5MC3, ATP5F1D, ATP6V0E1), proteasome (PSMB8), ubiquitin-like (NEDD8, SUMO2), and notably TCR signaling LCK/RAC2. The combination suggests a T-cell activation/effector module integrating cytoskeletal motility and metabolism with LCK as a T-cell-specific hub. Cytoskeletal/motility component is most coherent.
Genes
ATP5F1D, ATP5MC3, ATP6V0E1, BRK1, CAP1, LCK, MYL6, NEDD8, PPP1R18, PRDX5, PRR13, PSMB8, PTP4A2, RAC2, SRP14, SUMO2, TMEM59, TPM3, TRAPPC1, ZNRF1
Most correlated modules
- OxPhos & redox · correlation 0.94
- Actin cytoskeleton · correlation 0.91
- OxPhos & proteasome · correlation 0.89
- Interferon response · correlation 0.86
- Interferon Response · correlation 0.84
- Oxidative Phosphorylation · correlation 0.84
- CCR5 effector migration · correlation 0.81
- TCR Activation Signaling · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.