Metabolic reprogramming
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by metabolic/biosynthetic and nutrient-transport machinery: HMGCS1 and MYLIP/MYLIP-LDL (cholesterol/sterol biosynthesis), SLC2A1 (GLUT1, glucose transport), SLC1A5 (glutamine transporter), OAT (ornithine metabolism), KLF10 and RARA (metabolic/retinoic acid regulators). This is a classic activation-driven metabolic reprogramming signature (glycolysis, glutaminolysis, lipid synthesis) seen in effector CD4 T cells, strongly induced in inflamed CD tissue. Neighbors M108 (activation) and M49 (quiescence) frame this as the metabolic arm of T-cell activation.
Genes
ATG16L2, ATP1A1, CCNYL1, CSKMT, EIF1AY, FAM241A, HMGCS1, ING1, KLF10, LRRC75A, MORF4L2, MX2, MYLIP, NAA16, OAT, RARA, RBKS, RFLNB, SLC1A5, SLC2A1, USP53
Most correlated modules
- Vesicle Trafficking Signaling · correlation 0.79
- CD4 Lineage Identity · correlation 0.74
- Leukocyte Motility · correlation 0.71
- mRNA Splicing Processing · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.