TCR signaling
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 28 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 28 genes have a known function matching the annotation |
Why this annotation
Mixed activation/signaling module. CREM and RCAN3 are NFAT/calcineurin-related transcriptional regulators induced by TCR signaling; RNF125 (ubiquitin ligase regulating TCR signaling), SARAF (store-operated calcium regulator), STK4 (MST1, T cell signaling), PIK3R1, P2RY10 all reflect T cell activation/signaling. The presence of CREM, RCAN3, RNF125, SARAF points to a calcium/NFAT-linked TCR signaling program. delta_inflammation_CD significant supports an activation signature.
Genes
AP3M2, ATP1B3, CREM, CRYBG1, DCTN6, EZR, FAM177A1, FTH1, GCSAM, GNAQ, GPR183, GSPT1, ISCA1, LEPROTL1, MTERF4, NSMCE3, OSER1, P2RY10, PIK3R1, PPP1CB, RCAN3, RNF125, SARAF, SF1, SRGN, STK4, TBCC, USP36
Most correlated modules
- Immediate early activation · correlation 0.75
- TCR early activation · correlation 0.73
- Naive T quiescence · correlation 0.51
- DNA damage response · correlation 0.50
- Glucocorticoid Immunoregulation · correlation 0.45
- Naive T cell · correlation 0.45
- Naive resting T cell · correlation 0.44
- GIMAP survival · correlation 0.41
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.