Interferon response
Gene co-expression module in CD4⁺ T cells
| Category | Anti-viral |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
Top hubs are interferon-induced immunoproteasome and antigen presentation genes: UBE2L6, PSMB9, TAP1, PARP14, plus IL12RB1 (Th1/IFN responsive). UBE2L6/ISG15 pathway, PSMB9/TAP1 are classic interferon-stimulated genes. Inflammation-associated. This is an IFN-driven antigen processing/anti-viral type module.
Genes
ACTN4, CAPZA1, CHMP4A, CHMP5, EFHD2, IL12RB1, LSP1, PARP14, PIN1, PSMB9, RAB14, REEP5, SRI, SUMO3, TAP1, UBE2L6
Most correlated modules
- OxPhos & proteasome · correlation 0.90
- Cytoskeleton & metabolism · correlation 0.86
- Interferon Response · correlation 0.86
- JAK-STAT Signaling · correlation 0.84
- Actin cytoskeleton · correlation 0.83
- Mitochondrial Translation · correlation 0.83
- TCR Complex Activation · correlation 0.83
- Immune Regulation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.