Naive resting T cell
Gene co-expression module in CD4⁺ T cells
| Category | T cell development |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes ANKRD55, TSHZ2, RALGPS2, GCNT4 are characteristic markers of naive/resting CD4 T cells and quiescent memory cells. ANKRD55 is a well-known IBD/autoimmune GWAS locus and naive CD4 T-cell marker. ACTN1, ADD3, LMO7 add cytoskeletal stability of resting cells. The module reflects a naive/resting CD4 T-cell state.
Genes
ACTN1, ADD3, ALKBH7, ANKRD55, ARMH1, CEP170, EDAR, GCNT4, HOOK2, LMO7, MAML2, MYOM2, RALGPS2, TMEM243, TSHZ2, WDR74
Most correlated modules
- Naive T cell · correlation 0.77
- Naive T cell · correlation 0.76
- Immediate early activation · correlation 0.64
- T cell signaling · correlation 0.64
- Naive T quiescence · correlation 0.63
- NFAT activation · correlation 0.58
- Hypoxia metabolic stress · correlation 0.55
- CD200 immunoregulation · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.