TCR Complex Activation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 23 genes have a known function matching the annotation |
Why this annotation
This module contains the canonical T cell receptor/co-receptor complex genes CD3D, CD3E, CD3G, CD2, CD81, LAPTM5, plus effector cytokine IL26 (Th17-associated), GZMM (cytotoxic granule), ZEB2 and RBPJ (effector/Notch differentiation), FURIN (processes cytokines, Th-associated). The dominant identity is the core T cell identity/activation signature with a Th17 effector flavor (IL26, FURIN, RBPJ). Given CD3 complex hub genes, this reflects T cell identity rather than contamination since it is the expected lineage. Inflammation-upregulated. The mix of TCR complex and effector differentiation markers makes this a T cell activation/effector module.
Genes
ABHD17A, ACTR3, C1GALT1, CD2, CD3D, CD3E, CD3G, CD81, CERK, CMTM6, COL5A3, CPD, FURIN, GNAI2, GZMM, IL26, LAPTM5, MAN1A1, PAXX, RAP1B, RBPJ, TMEM167A, ZEB2
Most correlated modules
- Th17 effector · correlation 0.84
- Actin cytoskeleton · correlation 0.84
- Interferon response · correlation 0.83
- Integrin Rap1 Signaling · correlation 0.83
- Cytoskeleton & metabolism · correlation 0.80
- Rho-GTPase Migration · correlation 0.77
- JAK-STAT Signaling · correlation 0.76
- Inflammatory activation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.