Naive T quiescence
Gene co-expression module in CD4⁺ T cells
| Category | T cell development |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes KLF2, S1PR1, CCR7, SELL-associated, KLF3 define a classic naive/central memory T cell egress and quiescence program. KLF2 and S1PR1 control lymph node egress; CCR7 marks lymphoid homing; RASGRP2, RASA3 regulate integrin signaling. This is a lymphoid recirculation/naive T cell signature. Neighbor M39 (LEF1, SELL, TCF-like naive markers) supports a shared naive/quiescent T cell identity.
Genes
CCR7, CD55, CRIP2, CSGALNACT1, ITGA6, KLF2, KLF3, NOSIP, RASA3, RASGRP2, RIPOR2, S1PR1, SVIL, TSPAN18, VSIG1
Most correlated modules
- Naive T cell · correlation 0.89
- Naive T cell · correlation 0.68
- Hypoxia metabolic stress · correlation 0.66
- Naive resting T cell · correlation 0.63
- Immediate early activation · correlation 0.62
- TCR signaling · correlation 0.51
- T cell signaling · correlation 0.50
- GIMAP survival · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.