T-cell quiescence regulation
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Hubs FOXP1 (transcriptional repressor controlling T-cell quiescence), USP15 (deubiquitinase regulating TGF-beta/TCR signaling), CDKN1B (p27, cell-cycle/quiescence enforcer), and SMCHD1 point to a quiescence/homeostatic regulatory program rather than active proliferation. ICAM2 and CDC42SE2 add adhesion/cytoskeletal regulation. Module increases in inflammation and falls with treatment, consistent with a regulated T-cell state. The mix of weak-membership metabolic genes (SLC5A3, KRAS, MRPS6) indicates a moderately coherent program centered on transcriptional/quiescence control.
Genes
CDC42SE2, CDKN1B, FOXP1, ICAM2, KRAS, MRPS6, MSL3, SERINC5, SLC5A3, SMCHD1, SVIP, USP15, ZBTB1
Most correlated modules
- mRNA Processing · correlation 0.82
- T-cell costimulation · correlation 0.82
- Membrane Trafficking · correlation 0.80
- IL6-STAT3 Signaling · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.