Heat-shock response
Gene co-expression module in CD4⁺ T cells
| Category | Stress |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes are heat-shock / chaperone and co-chaperone genes: BAG3, AHSA1 (AHA1 HSP90 co-chaperone), FKBP4 (HSP90 co-chaperone), DNAJB6, HSPA6 (HSP70 family), CACYBP, plus stress-responsive GADD45G, MXD1, UBC (ubiquitin), MAP1LC3B (autophagy). This is a clear proteostatic / heat-shock stress response module. The uniform expression and moderate coherence and lack of cell-type enrichment support a general stress program induced during processing or in vivo stress.
Genes
AHSA1, BAG3, CACYBP, CCDC117, DNAJB6, DYNLL1, FKBP4, GADD45G, HSPA6, JMJD6, MAP1LC3B, MXD1, TSPOAP1, UBC
Most correlated modules
- Heat Shock Response · correlation 0.81
- DNA repair/replication · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.