Chromatin Regulation
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 26 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 26 genes have a known function matching the annotation |
Why this annotation
This module is enriched for chromatin/transcriptional regulators and nuclear factors: KAT6B (histone acetyltransferase), CHD3 (chromatin remodeler), ASXL2, HP1BP3, NPAT (histone gene transcription), ZNF638, DNTTIP2, PHIP. Mixed with these are signaling/immune genes (MAP3K1, CASP8, TRIM14, CTSS, PRKD3) and RNA-processing factors (PNISR, PDCD7). The dominant coherent theme among the strong-membership hubs is nuclear chromatin/transcriptional regulation. The moderate coherence and presence of disparate genes (CTSS, CASP8) reflect a mixed module, but the chromatin-regulator core drives the identity. Uniform expression argues against contamination.
Genes
ADI1, ASXL2, BTG3, CASP8, CHD3, CTSS, CWF19L2, DENND2D, DNTTIP2, FGFR1OP2, HP1BP3, IFT57, KAT6B, MAP3K1, NIN, NPAT, PDCD7, PHIP, PNISR, PRKD3, RLF, RPGR, SMARCA5, SREK1, TRIM14, ZNF638
Most correlated modules
- Vesicular trafficking · correlation 0.92
- Glycosylation & trafficking · correlation 0.78
- Chromatin regulation · correlation 0.77
- Epigenetic regulation · correlation 0.77
- PD-L1 checkpoint · correlation 0.77
- Oxidative phosphorylation · correlation 0.72
- Activated Effector ISG · correlation 0.69
- Chromatin transcription regulation · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.