mRNA Splicing Factors
Gene co-expression module in CD4⁺ T cells
| Category | RNA processing |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
Top genes are RNA-binding/splicing factors (HNRNPA2B1, CLK1, RSRC2, PRPF38B, FUS, ARGLU1) plus metabolic enzymes (MAT2A, GLS, ERO1B). The dominant program is splicing/RNA processing (HNRNPA2B1, CLK1, FUS, PRPF38B, RSRC2, ARGLU1). Neighbor of M79 which is also RNA processing, supporting this label.
Genes
ARGLU1, CDKN2D, CLK1, ERO1B, FUS, GLS, HNRNPA2B1, ID1, MAT2A, PAG1, PDE7A, PRPF38B, RASA2, RSRC2, SERP1, TTC39C, ZC3HAV1
Most correlated modules
- Transcriptional regulation · correlation 0.75
- Cytotoxic Effector CD4 · correlation 0.70
- Mixed Metabolic Ambient · correlation 0.68
- Activated Effector ISG · correlation 0.65
- Heat Shock Response · correlation 0.62
- RNA processing · correlation 0.62
- mRNA Splicing Processing · correlation 0.58
- Pol II Transcription Regulation · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.