Mitochondrial OxPhos
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 28 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 28 genes have a known function matching the annotation |
Why this annotation
Core module dominated by mitochondrial/OxPhos and electron transport genes: ATP5MF, UQCR10, MRPL52, MRPS34, TUFM, MDH1, HSD17B10, ATP6V0B, plus AURKAIP1 (mitochondrial translation regulator). Combined with proteasome (PSMC5) and splicing (SF3B6) housekeeping genes, but the predominant coherent theme is mitochondrial bioenergetics. Uniform low expression reflects broad metabolic housekeeping upregulated in inflammation.
Genes
AP2M1, ATP5MF, ATP6V0B, AURKAIP1, BSG, CALM3, CLTB, CSNK2B, ERH, HSD17B10, JTB, LAMTOR1, LAMTOR2, LMAN2, MDH1, MRPL52, MRPS34, NDUFAF3, PSMC5, RAC1, RNF181, RTF2, SF3B6, SNF8, SRSF9, SSNA1, TUFM, UQCR10
Most correlated modules
- Interferon-stimulated genes · correlation 0.95
- Proteasome translation · correlation 0.93
- ER protein processing · correlation 0.92
- Proteostasis OxPhos · correlation 0.90
- Activated effector Tcell · correlation 0.87
- Actin cytoskeleton · correlation 0.86
- Actomyosin signaling · correlation 0.84
- mRNA splicing · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.