MAF regulatory program
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 21 genes have a known function matching the annotation |
Why this annotation
Top hub MAF is the master TF for IL-10 and Tr1/Th17 regulation; SPOCK2, SLA (Src-like adaptor, TCR negative regulator), FYN (TCR kinase), PTPN2 (T cell signaling phosphatase, IBD risk gene), UCP2, NDUFV2, ISCU (metabolism). The combination of MAF, PTPN2, FYN, SLA points to a CD4 T cell regulatory/effector differentiation program. MAF strongly drives this. Best classed as immune regulation (MAF-driven regulatory program).
Genes
AKAP13, ARID4B, DTHD1, FYN, IKZF3, ISCU, LIMA1, LIMS1, MAF, NAB1, NAP1L4, NDUFV2, PTPN2, RAB11FIP1, RNF19A, SEC11A, SLA, SPOCK2, SYT11, TRPS1, UCP2
Most correlated modules
- mRNA stability regulation · correlation 0.86
- T-cell activation · correlation 0.83
- T cell exhaustion · correlation 0.82
- T Cell Signaling · correlation 0.79
- Cell cycle regulators · correlation 0.77
- MAPK feedback signaling · correlation 0.77
- NF-kB feedback · correlation 0.76
- TCR Activation Signaling · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.