OxPhos & redox
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hubs are proteasome maturation (POMP, PSMA4), OxPhos complex I (NDUFAB1, NDUFB2, NDUFB1), mito ribosome (MRPS21), redox (TXN, ATOX1, CHCHD2). Mixed metabolic/proteostasis module dominated by mitochondrial OxPhos and antioxidant genes. Uniform expression.
Genes
ATOX1, CHCHD2, HNRNPR, KIF5B, MRPS21, NDUFAB1, NDUFB1, NDUFB2, POMP, PSMA4, SNRPD3, SUB1, TPM4, TXN
Most correlated modules
- Cytoskeleton & metabolism · correlation 0.94
- OxPhos & proteasome · correlation 0.88
- T cell activation · correlation 0.86
- Actin cytoskeleton · correlation 0.84
- Oxidative Phosphorylation · correlation 0.83
- CCR5 effector migration · correlation 0.83
- Oxidative Phosphorylation · correlation 0.82
- Interferon response · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.