CD200 immunoregulation
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 32 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 32 genes have a known function matching the annotation |
Why this annotation
Hub genes CD200, TIAM1, FGFR1, NMB, CAV1, TWIST1, FBLN7 are a heterogeneous mix. CD200 is an immunoregulatory checkpoint expressed on Tfh cells, and this module sits in a Tfh-enriched neighborhood (M67, M137). However many genes (FGFR1, TWIST1, FBLN7, CAV1) are stromal/EMT-associated, suggesting a mixed module with weak T-cell specificity. Given the Tfh neighborhood and CD200, the immunoregulatory interpretation is favored but coherence to a single program is limited.
Genes
B3GNT2, CAV1, CD200, CD79A, CH25H, CHGB, DUOX1, ELF2, EVI5, FAM43A, FBLN7, FGFR1, HELLS, HMCES, HSPA12A, IGFL2, JADE2, LHFPL6, LRRC8B, MAGEF1, MAL, MAP7, MYCBP2, NMB, PGM2L1, POU3F1, SESN3, SHF, TCP11L2, TIAM1, TOPORS, TWIST1
Most correlated modules
- NFAT activation · correlation 0.81
- Tfh program · correlation 0.79
- Tfh CXCL13 program · correlation 0.72
- Treg regulation · correlation 0.71
- Proliferation/differentiation · correlation 0.59
- IL6-STAT3 Signaling · correlation 0.58
- TCR signaling activation · correlation 0.57
- Tfh IL21 help · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.