Endolysosomal Autophagy
Gene co-expression module in Colorectal carcinoma
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
TMEM59 (lysosomal membrane protein regulating APP processing), CD63 (late endosome/lysosome tetraspanin), ATP6V0E1 and ATP6V1G1 (V-ATPase subunits essential for lysosomal acidification), CHMP5 (ESCRT-III complex for multivesicular body biogenesis), VAMP8 (lysosomal SNARE for membrane fusion), RAB25 (apical recycling endosome GTPase), and GABARAPL2 (autophagosome membrane LC3 family) collectively define the endolysosomal and autophagy trafficking system. EPCAM and SPINT2 are epithelial markers consistent with CRC epithelial identity. This module is a strong, coherent endolysosomal/autophagy trafficking program.
Genes
Most correlated modules
- Actin-Vesicle Coupling · correlation 0.84
- ER-Golgi Trafficking · correlation 0.84
- ER Signal Peptide Processing · correlation 0.83
- ER Protein Processing · correlation 0.83
- Metabolic Stress Response · correlation 0.82
- ER Protein Processing · correlation 0.81
- Endosomal Vesicle Recycling · correlation 0.81
- Lysosomal Autophagy Membrane · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.