Actin-Vesicle Coupling
Gene co-expression module in Colorectal carcinoma
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
RAC1 (Rho GTPase regulating actin polymerization and vesicle trafficking), ARPC1A and ARPC2 (Arp2/3 complex subunits driving branched actin nucleation), and CALM1 (calmodulin, calcium sensor for cytoskeletal dynamics) define an actin cytoskeleton remodeling program. Simultaneously, KDELR2 (KDEL receptor for ER protein retrieval), TMED2 (p24 COPI vesicle), RAB2A (ER-Golgi GTPase), and SEC61G (translocon gamma subunit) reflect ER-Golgi trafficking. This moderate-coherence module bridges actin-based vesicle motility and ER/Golgi membrane trafficking, which are mechanistically linked via RAC1-driven vesicle movement. The neighbor context (M5 = ER-Golgi, M11 = endolysosomal) supports this interpretation.
Genes
Most correlated modules
- ER Protein Processing · correlation 0.87
- ER Protein Processing · correlation 0.86
- Endolysosomal Autophagy · correlation 0.84
- Actin Cytoskeleton Regulation · correlation 0.82
- ER Signal Peptide Processing · correlation 0.82
- Mitochondrial Import & Complex I · correlation 0.82
- Metabolic Stress Response · correlation 0.81
- ER-Golgi Trafficking · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.