ER Protein Processing
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
All hub and peripheral genes encode components of the ER translocon, OST complex, protein disulfide isomerase family, and ER retention machinery (SPCS2, SSR3, OSTC, DDOST, DAD1, KDELR1, PDIA6). This is a tight, uniform-expression housekeeping module representing co-translational ER protein processing and N-glycosylation.
Genes
Most correlated modules
- ER-Golgi Trafficking · correlation 0.91
- ER-Golgi Membrane Maintenance · correlation 0.89
- Actin-Vesicle Coupling · correlation 0.87
- Ubiquitin-Proteasome System · correlation 0.87
- Actin Cytoskeleton Regulation · correlation 0.87
- hnRNP RNA Processing · correlation 0.85
- Housekeeping Proteostasis · correlation 0.83
- Endosomal Vesicle Recycling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.