ER Protein Processing
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
This module mixes two related housekeeping programs co-expressed in CRC cells. OST4 and TMEM258 are subunits of the oligosaccharyltransferase complex (N-glycosylation in ER), SEC61B is the translocon beta subunit, and LAMTOR5/BRK1 are lysosomal/signaling components. NDUFB4 (NADH:ubiquinone oxidoreductase subunit), COX7A2 (cytochrome c oxidase subunit), HIGD2A (COX assembly factor), and GHITM (mitochondrial) reflect mitochondrial OxPhos. The co-expression of ER translocon and mitochondrial respiratory chain subunits reflects coordinated housekeeping translation and energy production. The dominant ER/glycosylation signal and strong coherence suggest the primary program is ER protein processing with mitochondrial co-regulation.
Genes
Most correlated modules
- OxPhos Complex III/IV · correlation 0.90
- SUMOylation Pathway · correlation 0.90
- Oxidative Phosphorylation ETC · correlation 0.87
- Proteasome Ubiquitin Degradation · correlation 0.87
- Mitochondrial Import & Complex I · correlation 0.87
- Actin-Vesicle Coupling · correlation 0.86
- ER Signal Peptide Processing · correlation 0.84
- Actin Cytoskeleton Regulation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.