STAT3 Oncogenic Signaling
Gene co-expression module in Colorectal carcinoma
| Category | GF response |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
STAT3 (master oncogenic transcription factor in CRC), DDR1 (discoidin domain receptor activated by collagen, promotes tumor growth), TAPBP (tapasin, MHC-I antigen presentation/immune evasion context), CTSD (cathepsin D, lysosomal protease upregulated in CRC), CD151 (tetraspanin promoting invasion), NFKBIZ (NF-κB modulator), CEACAM7 (carcinoembryonic antigen family), TRIM31 (E3 ubiquitin ligase), CDHR5 (cadherin-related), and MISP (mitotic spindle positioning) suggest a STAT3/NF-κB driven oncogenic epithelial signaling module with immune and adhesion components.
Genes
Most correlated modules
- Epithelial Junctional Cytoskeleton · correlation 0.90
- Epithelial Cell Adhesion · correlation 0.86
- Colonocyte Differentiation · correlation 0.85
- Complement Immune Evasion · correlation 0.84
- Epithelial Cell Junctions · correlation 0.80
- ECM Invasion Program · correlation 0.80
- Growth Arrest Senescence · correlation 0.77
- Hypoxia Response · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.