ECM Invasion Program
Gene co-expression module in Colorectal carcinoma
| Category | Invasion & metastses |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes PLAUR (uPAR, plasminogen activator receptor driving ECM proteolysis), LAMB3 (laminin beta-3, basement membrane invasion), EPHA2 (receptor tyrosine kinase promoting invasion/EMT), ITGB4 (integrin beta-4, hemidesmosome/invasion), ADAM9 (metalloprotease shedding ECM), EZR (ezrin, linking membrane to actin for invadopodia), and PLEC (plectin, cytoskeletal scaffold) collectively define a matrix invasion/metastasis program. CD55 adds immune evasion. ERO1A links to hypoxic ER oxidative folding supporting invasive phenotype. This is a coherent pro-invasive CRC module.
Genes
Most correlated modules
- Complement Immune Evasion · correlation 0.91
- Growth Arrest Senescence · correlation 0.91
- NF-κB Chemokine Response · correlation 0.83
- Epithelial Junctional Cytoskeleton · correlation 0.81
- STAT3 Oncogenic Signaling · correlation 0.80
- Colonocyte Differentiation · correlation 0.77
- Tight Junction Integrity · correlation 0.77
- Epithelial Cell Adhesion · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.