Ribosome Biogenesis
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
NOLC1 (nucleolar/rRNA processing), NOP58, NOP56 (box C/D snoRNP, rRNA methylation), GNL3 (nucleostemin, nucleolar GTPase), DDX18, DDX21 (DEAD-box helicases involved in ribosome biogenesis), EIF5B, EIF3B (translation initiation), PRKDC (DNA-PKcs, DNA repair but also nucleolar), TRIM28 (chromatin/transcription). The dominant theme is nucleolar ribosome biogenesis — rRNA processing and ribosome assembly. Core coherence and multiple canonical nucleolar factors confirm this tightly defined program.
Genes
Most correlated modules
- Pre-mRNA Splicing · correlation 0.88
- Chromatin-coupled Splicing · correlation 0.86
- RNA-protein Transport · correlation 0.85
- Post-transcriptional Regulation · correlation 0.84
- Chromatin & DNA Repair · correlation 0.83
- RNA Splicing · correlation 0.72
- WNT Stem Cell · correlation 0.70
- Ceramide Lipid Metabolism · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.