eIF3 Translation Initiation
Gene co-expression module in Colorectal carcinoma
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Three of the top four hub genes — EIF3K, EIF3F, and EIF3L — are canonical subunits of the eukaryotic translation initiation factor 3 (eIF3) complex, the largest initiation factor that coordinates 43S pre-initiation complex assembly. EEF1B2 is the translation elongation factor eEF1B2 (guanine nucleotide exchange for eEF1A). RACK1 is an established ribosome-associated scaffold. This module is a tight eIF3/translation initiation complex. COX4I1 (Complex IV) reflects the mitochondrial neighborhood co-expression. This is the clearest translation initiation module in the batch.
Genes
Most correlated modules
- Core Cellular Machinery · correlation 0.87
- Housekeeping Mixed · correlation 0.86
- RNA Processing & Biogenesis · correlation 0.86
- Mitochondrial Import & Complex I · correlation 0.84
- OxPhos Complex III/IV · correlation 0.83
- SUMOylation Pathway · correlation 0.83
- Mitoribosome Biogenesis · correlation 0.83
- Translation Initiation Factors · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.