Myeloid Inhibitory Receptors
Gene co-expression module in Dendritic cells
| Category | Tolerance |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
The top hub genes are CD33 (myeloid inhibitory receptor, cDC2-enriched), CD300LF and CD300C (paired immunoglobulin-like receptors that inhibit myeloid cell activation), and LTB4R (leukotriene B4 receptor, mediates inflammatory lipid signaling). FES is a myeloid-expressed tyrosine kinase involved in myeloid differentiation and phagocyte signaling. LGALS8 (galectin-8) modulates innate immune responses. CARD8 is an inflammasome regulator. ARHGAP4 is a Rho-GAP expressed in myeloid cells. CNPY3 assists TLR folding. FXYD5 modulates cell adhesion. The module is strongly enriched in cDC2 and represents a coherent myeloid inhibitory/regulatory receptor program. The neighbor context (M57 has XBP1/HAVCR2 tolerance-related genes) supports a regulatory/tolerogenic cDC2 identity. CARD8 and LTB4R add an inflammasome/lipid-sensing dimension, but the dominant theme is myeloid inhibitory receptor co-expression on cDC2.
Genes
Most correlated modules
- cDC2 CLR Signaling · correlation 0.93
- cDC2 Identity · correlation 0.92
- Focal Adhesion Remodeling · correlation 0.92
- Tolerogenic DC State · correlation 0.90
- cDC2 Identity · correlation 0.88
- TLR-MYD88 Signaling · correlation 0.88
- Gut-Homing DC · correlation 0.88
- DNA Damage Response · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.