Endosomal Retromer Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub gene SKAP2 is an adaptor in Src/integrin signaling important for DC and macrophage function. VPS35 is the core retromer subunit mediating endosomal cargo retrieval. STX10 is a syntaxin involved in late endosome/TGN trafficking. NAGA is a lysosomal alpha-N-acetylgalactosaminidase. OSBPL8 mediates lipid transfer at endosomal membranes. RAP1A and SIPA1 (Rap1 GAP) regulate integrin-mediated adhesion. TLN1 (talin) is a key integrin-actin linker. MAP4K1 (HPK1) is a hematopoietic kinase regulating immune receptor signaling. PTPN6 (SHP-1) is a phosphatase that modulates immune activation thresholds. ACTR2 (Arp2/3) connects to actin-driven endosomal dynamics. LPCAT2 remodels phospholipids on endosomal membranes. The dominant theme is endosomal/retromer vesicular trafficking integrated with immune receptor signaling, consistent with DC antigen processing logistics. Neighbor M85 shares cytoskeletal components, supporting actin-driven vesicular transport.
Genes
Most correlated modules
- Oxidative Stress Response · correlation 0.91
- Myeloid DC Identity · correlation 0.91
- Lysosomal Vesicular Trafficking · correlation 0.90
- G1/S Cell Cycle · correlation 0.89
- Actin Polymerization · correlation 0.88
- TLR-MYD88 Signaling · correlation 0.85
- Gut-Homing DC · correlation 0.84
- DNA Damage Response · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.