Lysosomal Vesicular Trafficking
Gene co-expression module in Dendritic cells
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Moderate coherence module with mixed but related programs. LRBA (autophagy/vesicular trafficking regulator), CTSD (cathepsin D, lysosomal protease), NCOA4 (ferritinophagy receptor), SRPRB (SRP receptor, ER protein targeting), SYPL1 (vesicle-associated), and TMBIM4 (ER membrane) collectively point to lysosomal and ER-associated vesicular trafficking. BTK and RAC2 add myeloid signaling context. PTGS1 (COX-1) contributes prostaglandin synthesis. The module likely captures a combined ER-to-lysosome trafficking and degradative program in DCs, consistent with antigen processing support functions.
Genes
Most correlated modules
- Endosomal Retromer Trafficking · correlation 0.90
- DC Actin Migration · correlation 0.89
- Gut-Homing DC · correlation 0.87
- ER Protein Biogenesis · correlation 0.87
- Golgi-Endosomal Trafficking · correlation 0.86
- Tolerogenic DC State · correlation 0.85
- DNA Damage Response · correlation 0.85
- Myeloid Inhibitory Receptors · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.