cDC2 Identity
Gene co-expression module in Dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 15 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes ITGAM (CD11b), ASGR1, CLEC12A, ANXA1, LAPTM5, TBXAS1, and LCP2 are canonical cDC2 surface receptors and myeloid signaling molecules. RARA encodes the retinoic acid receptor alpha, critical for gut DC tolerogenic identity. The module is strongly enriched in cDC2 across nearly all genes, with strong coherence. This represents the cDC2 lineage identity program in the gut, combining myeloid surface markers, lipid mediator synthesis (TBXAS1), and retinoic acid responsiveness (RARA).
Genes
Most correlated modules
- cDC2 Identity · correlation 0.94
- Myeloid Inhibitory Receptors · correlation 0.92
- Endosomal Trafficking · correlation 0.92
- cDC2 CLR Signaling · correlation 0.91
- cDC2 Identity · correlation 0.91
- Tolerogenic DC State · correlation 0.90
- cDC2 Identity · correlation 0.88
- TLR-MYD88 Signaling · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.