cDC2 CLR Signaling
Gene co-expression module in Dendritic cells
| Category | Pathogen response |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Despite the header indicating cDC1 (20.4x) enrichment at the module level, the individual gene top-subset annotations are predominantly cDC2. MEF2C (master myeloid transcription factor critical for cDC2 development), CARD9 (CLR/Dectin signaling adaptor, cDC2-relevant), CD101 (immune checkpoint, cDC2-enriched), CD300A (inhibitory receptor), MAML3 (Notch coactivator), RNF125 (ubiquitin E3 ligase regulating innate signaling), MYO1F (myosin Ic, phagocytosis), PLCB2 (PLCβ2, downstream of CLRs), and ADCY7 (adenylyl cyclase) collectively suggest a cDC2 transcriptional identity and innate sensing program. HRH2 (histamine H2 receptor, anti-inflammatory cAMP signaling) and LRRC25 (negative regulator of ISG15/innate immunity) add regulatory nuance. The module likely represents a cDC2 regulatory/identity program with CLR signaling components.
Genes
Most correlated modules
- Myeloid Inhibitory Receptors · correlation 0.93
- Tolerogenic DC State · correlation 0.92
- cDC2 Identity · correlation 0.91
- TLR-MYD88 Signaling · correlation 0.89
- cDC2 Identity · correlation 0.89
- Focal Adhesion Remodeling · correlation 0.86
- cDC2 Identity · correlation 0.85
- p53 Transcriptional Regulation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.