RNA Splicing Processing
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include DDX17, DDX5, SRSF5, RBBP6, DDX3Y, RBM5, YTHDC1, NUFIP2 — all RNA helicases, splicing factors, or RNA-binding proteins involved in RNA processing and splicing regulation. ZKSCAN1 and ZNF207 are zinc finger transcriptional regulators. CIITA is a master regulator of MHC class II expression, and STAT6 is a cytokine signaling transcription factor relevant to DC biology. TOB1 is an anti-proliferative gene. MANBA is a lysosomal enzyme. The dominant theme is RNA processing/splicing (DDX17, DDX5, SRSF5, RBM5, YTHDC1, NUFIP2, RBBP6), with CIITA and STAT6 as notable DC-relevant members. The module likely reflects a basal RNA metabolism and splicing program in DCs, with CIITA co-regulated as part of DC identity.
Genes
Most correlated modules
- Immediate Early Response · correlation 0.91
- Transcriptional Homeostasis · correlation 0.91
- Actin Cytoskeletal Remodeling · correlation 0.88
- Alternative Splicing · correlation 0.87
- p53 Transcriptional Regulation · correlation 0.86
- Proliferating DC Program · correlation 0.84
- Chromatin Remodeling · correlation 0.84
- Glucocorticoid Stress Response · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.