Transcriptional Homeostasis
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include KMT2C (histone H3K4 methyltransferase), SAFB2 (scaffold attachment/RNA processing), TSPYL2 (nucleosome assembly repressor), HIPK3 (transcriptional co-repressor kinase), ZBTB20 and FOXN2 (zinc finger TFs), RNF139 and UBE2R2 (ubiquitin machinery), and MAP3K2/TYK2 (kinase signaling). Uniform expression across DC subsets. The module combines chromatin/epigenetic regulation with ubiquitin-proteasome components and transcription factors, suggesting a general transcriptional homeostasis program. SOCS4 and TYK2 add a cytokine-signaling suppression flavor. Moderate coherence reflects the breadth of the program rather than a tight single pathway.
Genes
Most correlated modules
- RNA Splicing Processing · correlation 0.91
- Proliferating DC Program · correlation 0.89
- Phagocytic Cytoskeletal · correlation 0.87
- p53 Transcriptional Regulation · correlation 0.85
- Chromatin Remodeling · correlation 0.85
- Alternative Splicing · correlation 0.84
- Immediate Early Response · correlation 0.84
- Genome Maintenance · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.