Vesicular Housekeeping
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
This module has moderate-to-low expression and uniform distribution across subsets with some prolif_DC enrichment. Hub genes include CBL (E3 ubiquitin ligase, signal termination), TMED3 (COPI vesicle trafficking), MLEC (lectin/glycoprotein folding in ER), EXOC6 (exocyst complex, vesicle docking), TMEM50B (transmembrane), SSRP1 (chromatin remodeling/FACT complex), AHCY (methionine cycle), IMPA2 (inositol metabolism), GALK1 (galactose metabolism). DCLRE1C (DNA repair), DDX18 (RNA helicase), APBB1IP (actin/signaling). The mix of vesicle trafficking (TMED3, EXOC6, MLEC), ubiquitin signaling (CBL), and metabolic genes (AHCY, GALK1, IMPA2) alongside prolif_DC enrichment suggests a housekeeping/metabolic support program active in proliferating DCs. TMED3 and EXOC6 point toward vesicular trafficking. The module is a mixed housekeeping program but vesicular trafficking genes are notable. Given the neighbor context (M3 is OxPhos, M157/M129 are proliferation-linked), this module likely represents general housekeeping with vesicular trafficking components in proliferating DCs.
Genes
Most correlated modules
- Ribosome Biogenesis · correlation 0.94
- Mitochondrial DNA Repair · correlation 0.93
- Mitochondrial OxPhos · correlation 0.93
- Endosomal Vesicle Trafficking · correlation 0.93
- MYC-driven Proliferation · correlation 0.91
- Telomere Maintenance · correlation 0.91
- Ribosome Biogenesis · correlation 0.90
- ER Protein Biogenesis · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.