Mitochondrial DNA Repair
Gene co-expression module in Dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include HADHA (mitochondrial trifunctional protein, fatty acid beta-oxidation), NDUFB5 (Complex I subunit), UFC1 (UFMylation E2 enzyme, ER stress/ribosome quality control), JTB (jumping translocation breakpoint, mitochondria-associated), MIF4GD (eIF4G domain, translation), PRKDC (DNA-PK catalytic subunit, DNA repair/V(D)J recombination), ABRACL (actin dynamics), SMC1A (cohesin, DNA repair/cell cycle), NHP2 (H/ACA snoRNP, ribosome biogenesis), SH3BP1 (Rho GAP), PPHLN1 (nuclear lamina), HAGH (lactoylglutathione lyase, methylglyoxal detox), ANP32A (chromatin/apoptosis). Module coherence is strong but gene membership is mostly 'strong' or 'moderate'. The module is a mixed bag: mitochondrial metabolism (HADHA, NDUFB5), DNA repair (PRKDC, SMC1A), and RNA processing (NHP2, MIF4GD). PRKDC and SMC1A enriched in prolif_DC suggest a DNA damage/repair component in proliferating DCs. The most coherent sub-theme linking HADHA, NDUFB5, and metabolic genes is mitochondrial function, but PRKDC/SMC1A add a DNA repair flavor. Given the neighbor context (M89, M23 are proliferation modules), this likely represents a mixed mitochondrial-DNA repair program in proliferating DCs.
Genes
Most correlated modules
- Vesicular Housekeeping · correlation 0.93
- Ribosome Biogenesis · correlation 0.93
- Oxidative Stress Response · correlation 0.92
- Ribosome Biogenesis · correlation 0.92
- Mitochondrial OxPhos · correlation 0.91
- Mitochondrial OxPhos · correlation 0.91
- RNA Splicing Processing · correlation 0.91
- Mitochondrial Biogenesis · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.