Ribosome Biogenesis
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include MRPL4 (mitochondrial ribosomal protein), IMP4 (rRNA processing/ribosome biogenesis), EXOSC5/EXOSC7 (RNA exosome complex, rRNA/mRNA processing), IDH3A (TCA cycle isocitrate dehydrogenase), ECHDC1 (fatty acid metabolism), EIF2B1 (translation initiation), ABCE1 (ribosome recycling), RRP15/UTP3 (ribosome biogenesis), NIFK (ribosome biogenesis/Ki-67 interactor), NUP37 (nuclear pore), EEF1E1 (translation). This module is strongly enriched for ribosome biogenesis and RNA processing machinery. Some prolif_DC enrichment is consistent with elevated ribosome biogenesis in proliferating cells. IDH3A and ECHDC1 add metabolic flavor. The dominant program is ribosome biogenesis/RNA processing.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.94
- Mitochondrial DNA Repair · correlation 0.92
- Spliceosome RNA Processing · correlation 0.91
- Vesicular Housekeeping · correlation 0.90
- G1/S Cell Cycle · correlation 0.89
- Mitochondrial Metabolism UCP2 · correlation 0.88
- Oxidative Stress Response · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.