TLR-MYD88 Signaling
Gene co-expression module in Dendritic cells
| Category | Pathogen response |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
MYD88 (universal TLR/IL-1R adaptor) and SCIMP (transmembrane scaffold that recruits SYK and facilitates TLR4 signaling in myeloid cells) are the top two hub genes and define a TLR signaling program. CD1D (lipid antigen presentation to NKT cells) and SNX18 (endosomal sorting for antigen presentation) add a lipid antigen presentation dimension. PLAC8 (antimicrobial), MNDA (myeloid nuclear differentiation antigen), ITGB2 (integrin, adhesion/phagocytosis), VSIR (V-domain Ig suppressor of T-cell activation, immune checkpoint), and RGS18 (G-protein regulator) are consistent with a cDC2 innate sensing and lipid antigen presentation state. Module is cDC2-enriched and shows a trend toward upregulation in CD inflammation.
Genes
Most correlated modules
- cDC2 CLR Signaling · correlation 0.89
- Tolerogenic DC State · correlation 0.89
- Myeloid Inhibitory Receptors · correlation 0.88
- Myeloid DC Identity · correlation 0.87
- cDC2 Identity · correlation 0.85
- Endosomal Retromer Trafficking · correlation 0.85
- Focal Adhesion Remodeling · correlation 0.85
- cDC2 Identity · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.