Tolerogenic DC State
Gene co-expression module in Dendritic cells
| Category | Tolerance |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes TGFBI (TGF-β-induced ECM/tolerance gene), FGL2 (immunosuppressive fibrinogen-like protein), ADA2 (adenosine deaminase 2, purinergic immune regulation), FCGRT (FcRn, IgG homeostasis), HLA-DMB (MHC II peptide loading), PSAP (lysosomal sphingolipid processing), HEXB (lysosomal β-hexosaminidase), and TIMP2 (MMP inhibitor) collectively define a tolerogenic DC program with lysosomal antigen processing features. AOAH deacylates LPS reducing inflammatory signaling. The module is uniformly expressed, slightly downregulated with inflammation, consistent with homeostatic/tolerogenic DC identity. Neighbor M83 is a transcriptional regulatory module, and M132 is a TLR/cDC2 module — M84 occupies the tolerogenic niche in this neighborhood.
Genes
Most correlated modules
- cDC2 CLR Signaling · correlation 0.92
- Myeloid Inhibitory Receptors · correlation 0.90
- cDC2 Identity · correlation 0.90
- Focal Adhesion Remodeling · correlation 0.90
- TLR-MYD88 Signaling · correlation 0.89
- Gut-Homing DC · correlation 0.88
- Lysosomal Vesicular Trafficking · correlation 0.85
- Myeloid DC Identity · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.