cDC2 Identity
Gene co-expression module in Dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
FCER1A (high-affinity IgE receptor alpha chain) and CD1C are canonical cDC2 identity markers in human gut. JAML (junction adhesion molecule-like, expressed on cDC2), LST1 (leukocyte-specific transcript 1, myeloid), IL1R2 (IL-1 decoy receptor, anti-inflammatory), CD302 (C-type lectin, cDC2), PLD4 (phospholipase D4, expressed in cDC2), and GRIP1 are all cDC2-enriched. The module is significantly downregulated with inflammation (delta_inflammation = -0.640, sig.), indicating this is a homeostatic cDC2 identity program that is lost during intestinal inflammation. This is the clearest cDC2 identity module in the batch.
Genes
Most correlated modules
- cDC2 Identity · correlation 0.89
- Myeloid Inhibitory Receptors · correlation 0.88
- cDC2 Identity · correlation 0.88
- cDC2 CLR Signaling · correlation 0.85
- Focal Adhesion Remodeling · correlation 0.83
- Endosomal Trafficking · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.