Tolerogenic DC Signaling
Gene co-expression module in Dendritic cells
| Category | Tolerance |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
LILRB1 and LILRB3 are inhibitory immunoreceptors that suppress DC activation; TGFB1 drives tolerogenic DC differentiation; FGR and SRC are Src-family kinases that mediate inhibitory receptor signaling; NCF2 participates in oxidative burst regulation; ITGAX (CD11c) confirms DC identity. The combination of inhibitory receptors (LILRB1/3), tolerogenic cytokine (TGFB1), and signaling kinases (FGR, SRC, GRB2, SH3BP2, SH2B2) suggests a tolerogenic/inhibitory signaling state. Neighbor M116 defines cDC2 identity; this module captures a functional tolerogenic arm of cDC2s. The prolif_DC enrichment may reflect that proliferating DCs maintain this inhibitory program.
Genes
Most correlated modules
- cDC2 Identity · correlation 0.85
- DC Proliferation Program · correlation 0.84
- DC Metabolic Activation · correlation 0.83
- cDC2 Identity · correlation 0.82
- OLR1+ cDC2 Subset · correlation 0.80
- Innate Myeloid Sensing · correlation 0.80
- Tolerogenic Lipid Metabolism · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.