cDC2 Identity
Gene co-expression module in Dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include canonical cDC2 identity and differentiation factors: NOTCH2 and RXRA (master cDC2 transcription factors), CCR2 (monocyte/cDC2 recruitment), CD14 (monocyte/cDC2 surface marker), STAB1 (scavenger receptor), CFD (complement factor D), GIMAP4, ASGR2, CCR1, and S100A9. The module is strongly enriched in cDC2 subsets across multiple genes. This represents the core cDC2 identity/differentiation transcriptional program, distinguishing cDC2s from other DC subsets in the gut.
Genes
Most correlated modules
- cDC2 Identity · correlation 0.93
- cDC2 Identity · correlation 0.91
- cDC2 CLR Signaling · correlation 0.83
- Endosomal Trafficking · correlation 0.83
- Tolerogenic DC Signaling · correlation 0.82
- TLR-MYD88 Signaling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.