Cell Cycle Regulation
Gene co-expression module in Innate lymphoid cells
| Category | Cell cycle |
|---|---|
| Genes | 7 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 7 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression across subsets. TAF15 is an RNA polymerase II transcription factor. RAD21 is a cohesin subunit essential for sister chromatid cohesion and cell division. KIF2A is a kinesin involved in mitotic spindle organization. CDKN1B (p27/Kip1) is a cyclin-dependent kinase inhibitor regulating G1/S transition. FLI1 is an ETS transcription factor. TBRG1 is TGF-beta related. The combination of cohesin (RAD21), mitotic kinesin (KIF2A), and CDK inhibitor (CDKN1B) points to cell cycle regulation, though the module is weak and heterogeneous. The large positive delta_treatment response is notable but all n.s.
Genes
CDKN1B, FLI1, GLG1, KIF2A, RAD21, TAF15, TBRG1
Most correlated modules
- Interferon-Stimulated Genes · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.