CDKN1B — Cyclin dependent kinase inhibitor 1B
CDKN1B belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDKN1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell quiescence regulation Immune regulation | CDC42SE2, FOXP1, ICAM2, KRAS, MRPS6, MSL3, SERINC5, SLC5A3 +4 more | View in SCUBA |
| Innate lymphoid cells | Cell Cycle Regulation Cell cycle | FLI1, GLG1, KIF2A, RAD21, TAF15, TBRG1 | View in SCUBA |
| Macrophages | Anti-inflammatory Response Inflammatory | AMPD2, ARRDC2, BHLHE40, CBX4, CEBPD, CITED2, DENND3, EIF4B +31 more | View in SCUBA |
| Monocytes | ER Stress Response Stress | CFAP20, DDIT3, GIMAP5, HSPA5, KLF2, KLF4, ODC1, RHOB +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Co-transcriptional Splicing RNA processing & translation | C9orf78, CCDC85C, CCNK, DNTTIP2, EIF4B, ILF3, LAPTM5, MADD +16 more |
About the gene
| Synonyms | KIP1, P27KIP1 |
|---|---|
| Chromosome | 12: 12685498-12722369 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Protein kinase inhibitor |
| Biological process | Cell cycle |
Function
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.