TBRG1 — Transforming growth factor beta regulator 1
TBRG1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TBRG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | ANKRD10, ASF1A, DDX18, DNAJC17, ENPP5, KLRC4, KLRD1, NARS1 +15 more | |
| Innate lymphoid cells | Cell Cycle Regulation Cell cycle | CDKN1B, FLI1, GLG1, KIF2A, RAD21, TAF15 | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L +20 more | View in SCUBA |
About the gene
| Synonyms | FLJ14621, NIAM, TB-5 |
|---|---|
| Chromosome | 11: 124622836-124635926 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle |
Function
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.